Upper Airway Stimulation: An Implant Option for Sleep Apnea When CPAP Doesn't Work

Upper Airway Stimulation: An Implant Option for Sleep Apnea When CPAP Doesn't Work

3 January 2026 · 1 Comments

For millions of people with sleep apnea, the CPAP machine is a nightmare - not because it doesn’t work, but because it’s impossible to live with. The mask chafes. The hose tangles. The air pressure feels like a hurricane in your nose. And after weeks of frustration, most people just give up. That’s where upper airway stimulation comes in: a tiny, implantable device that treats sleep apnea without a mask, without noise, and without the daily struggle.

What Is Upper Airway Stimulation?

Upper airway stimulation (UAS) is a surgical therapy for obstructive sleep apnea that works by gently stimulating the nerve that controls your tongue. When you breathe in during sleep, the device sends a mild pulse to the hypoglossal nerve, which moves your tongue forward just enough to keep your airway open. No mask. No hose. No blowing air. Just a quiet, automatic fix that happens while you sleep.

The only FDA-approved system currently on the market is the Inspire UAS system. It’s been around since 2014, and over 200,000 people worldwide have had it implanted. Unlike CPAP, which forces air into your airway, UAS fixes the root problem: your tongue blocking your throat when you relax during sleep.

How Does the Inspire Device Work?

The Inspire system has three small parts implanted under your skin:

  • A thin wire (stimulation lead) that wraps around the nerve controlling your tongue
  • A second wire (sensing lead) that detects when you’re breathing in
  • A small battery-powered generator (about the size of a pacemaker) placed under your collarbone
All three pieces work together. The sensing lead picks up your breathing pattern. When it detects you’re inhaling, it triggers the stimulation lead to nudge your tongue forward. The whole process is automatic - no manual adjustments needed during the night.

You control the device with a small remote. Before bed, you press a button to turn it on. In the morning, you turn it off. That’s it. The device only activates during inhalation to avoid muscle fatigue. It doesn’t buzz, vibrate, or make noise. Most people forget it’s even there after a few weeks.

Who Is a Good Candidate?

This isn’t for everyone. The FDA and medical guidelines have clear rules for who qualifies:

  • You have moderate to severe obstructive sleep apnea (AHI between 15 and 100 events per hour)
  • You’ve tried CPAP and couldn’t stick with it - not because it didn’t work, but because you couldn’t tolerate it
  • Your body mass index (BMI) is under 35 (some centers allow up to 40)
  • You don’t have mostly central apneas (your problem is physical blockage, not brain signal failure)
  • You’re at least 22 years old
  • Your airway anatomy allows for the device to work - confirmed by a sleep endoscopy
If you’ve been on CPAP for months and still wake up gasping, or if you’ve never even tried it because you know you’ll hate it, UAS might be your best shot at real sleep.

What Happens During Surgery?

The surgery takes about 2 to 3 hours and is done as an outpatient procedure. You’ll be under general anesthesia, so you won’t feel a thing.

The surgeon makes three small incisions:

  • One in your neck to place the stimulation wire around the hypoglossal nerve
  • One lower in your neck to thread the sensing wire under your breastbone
  • One below your collarbone to tuck in the battery generator
Most people go home the same day. You’ll have some soreness for a few days, but no major pain. You can usually return to light activities within a week. Full recovery takes about 4 to 6 weeks.

The device isn’t turned on right away. You’ll wait about a month to let everything heal. Then, your sleep specialist will program it using a handheld device. They’ll test different stimulation levels to find what works best for you - just like tuning a CPAP machine, but without the mask.

A doctor shows a patient a floating diagram of the Inspire device’s three implanted components.

How Effective Is It?

The data speaks for itself. In the landmark STAR trial, patients saw their apnea-hypopnea index (AHI) drop from an average of 29.3 events per hour to just 9.0 after one year - a 68% reduction.

Two out of three patients had their AHI cut in half or more. Over 80% of users say they’d recommend the therapy to someone else. And 86% say it’s better than CPAP.

Real-world results are just as strong. A four-year follow-up from the Cleveland Clinic found that 85% of bed partners reported no snoring - or only soft snoring. Patients reported better sleep quality, less daytime fatigue, and improved mood.

One Reddit user wrote: “My wife says I’ve stopped snoring completely after two years. I feel more rested than I have in decades.”

How Does It Compare to CPAP?

CPAP is still the gold standard - if you can use it. But here’s the problem: 29% to 46% of people quit CPAP within the first year. The reasons? Discomfort, claustrophobia, dry mouth, noise, travel hassle.

UAS doesn’t solve every problem. But it solves the biggest one: adherence. People use Inspire an average of 7.5 hours per night. CPAP users average just 4 hours. That’s the difference between treatment and no treatment.

UAS also doesn’t require daily cleaning, mask replacements, or humidifiers. Once it’s implanted, it’s basically maintenance-free.

But UAS isn’t better in every way. CPAP works for almost everyone with obstructive apnea. UAS only works for a specific group. CPAP is non-invasive. UAS requires surgery. CPAP can be adjusted instantly. UAS needs a clinic visit to tweak settings.

It’s not about which is better - it’s about which one you can actually live with.

What Are the Risks?

The procedure is very safe. Major complications occur in less than 0.5% of cases. The most common side effects are mild and temporary:

  • Minor pain or swelling at the incision sites
  • Temporary tongue weakness (affects about 5% of patients, usually resolves in weeks)
  • Minor infections (about 2% of cases)
  • Discomfort from stimulation at first - most people get used to it within 2 to 3 weeks
There’s no risk of the device “failing” like a CPAP machine. If the battery dies (which takes about 10 years), you can replace it with a simple outpatient surgery.

Unlike tonsil removal or jaw surgery, UAS is reversible. You can have the device removed if you change your mind - no permanent damage to your airway.

Before-and-after scene: left shows CPAP struggle, right shows peaceful sleep with upper airway stimulation.

Cost and Insurance Coverage

The total cost of the procedure - device, surgery, hospital fees - averages between $35,000 and $40,000. That sounds steep, but it’s comparable to the long-term cost of CPAP when you factor in replacement masks, filters, humidifiers, and follow-up visits over 10 years.

Insurance coverage has improved dramatically. As of 2023, 95% of Medicare beneficiaries and 85% of privately insured patients have coverage for Inspire therapy. Most insurers require proof of CPAP failure before approving UAS.

If you’re denied coverage, many centers offer payment plans or financial assistance programs. The Inspire Patient Support Program helps navigate insurance and even connects you with others who’ve had the implant.

What’s Next for This Therapy?

The FDA expanded eligibility in 2023 to include patients with AHI up to 100 and BMI up to 40 - meaning more people qualify now than ever before.

Researchers are working on smaller devices, smarter algorithms that adapt to your breathing in real time, and AI tools to predict who will respond best before surgery.

The market is growing fast. Analysts expect the upper airway stimulation market to grow over 14% per year through 2028. As more doctors get trained and insurance coverage expands, this therapy will become more accessible.

Is It Right for You?

If you’ve been told you have sleep apnea and you’ve tried CPAP - and you hated it - then you’re not broken. You just need a different solution.

Upper airway stimulation isn’t magic. It’s not a cure. But for the right person, it’s life-changing. People who’ve had it describe waking up without grogginess, feeling alert during the day, and finally sleeping through the night without their partner nudging them.

Talk to a sleep specialist who has experience with UAS. Ask for a sleep endoscopy. Get your AHI and BMI checked. If you meet the criteria, this could be the first night of real sleep you’ve had in years.

Frequently Asked Questions

Is upper airway stimulation the same as a pacemaker?

It works similarly - both are implanted devices that send electrical pulses to regulate body function. But while a pacemaker controls heart rhythm, upper airway stimulation controls tongue movement to keep your airway open during sleep. The Inspire device is smaller, less complex, and only activates when you breathe in.

Can I have an MRI after getting the Inspire device?

Yes, but only under specific conditions. The Inspire device is MRI-conditional, meaning you can have an MRI scan of your head, neck, or extremities if the device is turned off and the scan follows strict safety guidelines. Full-body MRIs are not allowed. Always inform your radiology team you have an implanted device before any scan.

Will I feel the stimulation during the day?

No. The device only activates during sleep when you’re breathing in. During the day, it’s completely inactive. You won’t feel any movement, tingling, or pressure. Most users report forgetting it’s even there after a few weeks.

How long does the battery last?

The battery in the Inspire device lasts about 10 years on average. When it starts to run low, your doctor will schedule a simple outpatient procedure to replace the generator - similar to replacing a pacemaker battery. The leads (wires) stay in place, so it’s a much smaller surgery than the original implant.

Do I still need to lose weight if I get this implant?

Weight loss isn’t required to get the device, but it can improve results. People with higher BMI tend to have more severe sleep apnea, and losing even 10% of body weight can reduce apnea events significantly. Many patients find that after getting the device and sleeping better, they have more energy to exercise and make healthier choices - making weight loss easier over time.

Benjamin Vig
Benjamin Vig

I am a pharmaceutical specialist working in both research and clinical practice. I enjoy sharing insights from recent breakthroughs in medications and how they impact patient care. My work often involves reviewing supplement efficacy and exploring trends in disease management. My goal is to make complex pharmaceutical topics accessible to everyone.

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1 Comment
  • Jay Tejada
    Jay Tejada
    January 4, 2026 AT 12:31

    I tried CPAP for six months. Felt like a robot breathing through a snorkel. Then I got the Inspire. My wife says I sleep like a baby now. No more midnight elbow nudges. Best decision I ever made.

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